The 100µPET collaboration


The University of Geneva, the University Hospital of Luzern and the École Polytechnique Fédérale de Lausanne have launched the 100µPET project that aims to produce a small-animal PET scanner with ultra-high resolution. This prototype, which will use a stack of 60 monolithic silicon pixel sensors as a detection medium, will provide volumetric spatial resolution one order of magnitude better than today’s best operating PET scanners.

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Design and production of the 100μPET small-animal scanner
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Imaging with Machine Learning and Neural Networks to cope with the 10^15 possible lines-of-response
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Study the onset and progression of atherosclerotic plaques in arteries to better understand, monitor and treat atherosclerosis in ApoE+/- mice.
Imaging the unseen
We are developing high-resolution virtual models of mouse phantoms to exploit ultra-high resolution scanner.
Lines-of-response
Highly granular detection field-of-view allows to reconstruct with high accuracy volumetric shapes
New imaging techniques
To probe the smallest features, data reconstruction algorithms are being developed to exploit the highly granular measurement field-of-view.


The 100µPET scanner

The ultra-high resolution scanner will use a multilayer of monolithic silicon pixel sensors as a detection medium. In contrast to conventional PET scanners, the concept of the 100µPET project uses photons that are converted inside 50 µm lead sheets. The electrons produced are detected and measured in highly accurate monolithic silicon sensors with a thickness of 100 µm. A stack of 60 lead+silicon detection layers ensures high efficiency with a peak sensitivity of 4%. The scanner's spatial granularity of 100×100×200 µm3 will provide unmatched spatial resolution and revolutionary depth of interaction measurements in high quality imaging.